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1-Hydroxy-3-nitro-4-(3-hydroxypropylamino)benzene (see note 17)

CAS 92952-81-3
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-group hair dye intermediate restricted to 2.6% in EU cosmetics, causing skin irritation and long-term aquatic toxicity.

This nitroamino benzene compound (CAS 92952-81-3) is a hair dye precursor restricted under EU Regulation 1223/2009 Annex III to a maximum concentration of 2.6% in the final cosmetic preparation. H315 indicates skin irritation potential, and H411 signifies long-lasting aquatic toxicity requiring environmental precautions in manufacturing waste handling. Hair dye intermediates of this class are subject to strict concentration limits and mandatory oxidative coupling conditions to ensure safe transformation into stable colourants.

Known concerns

  • H315 — skin irritant
  • H411 — toxic to aquatic life with long-lasting effects
  • EU Annex III restricted to ≤2.6% in hair dye formulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.