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4-Hydroxy-2,5,6- triaminopyrimidine sulfate

CAS 1603-02-7
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An oxidative hair dye intermediate used in permanent hair coloration. Classified with EU hazard statements for skin, eye, and respiratory irritation, requiring careful formulation handling.

This triaminopyrimidine sulfate is an oxidative hair dye precursor used in permanent hair dye formulations, where it reacts with couplers and oxidizing agents to form colored compounds. The EU GHS classification includes H315 (skin irritation), H319 (serious eye irritation), and H335 (respiratory irritation). While approved for use in hair dye formulations under EU cosmetic regulation with specific concentration limits, it requires careful handling during manufacturing and formulation. The presence of the sulfate group may increase water solubility and potential for skin exposure.

Skin benefits

  • Used as hair dye intermediate for permanent coloration
  • Contributes to long-lasting hair color results

Known concerns

  • H315 - causes skin irritation
  • H319 - causes serious eye irritation
  • H335 - may cause respiratory irritation
  • Sensitization potential in hair dye context
  • Requires careful handling during formulation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.