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4-Benzyloxyphenol and 4-ethoxyphenol

CAS 103-16-2 / 622-62-8
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A mixture of phenolic compounds historically used as antioxidants or intermediates in cosmetic formulations, now subject to strict EU restrictions as hair dye precursors.

This ingredient represents a mixture of 4-Benzyloxyphenol (CAS 103-16-2) and 4-Ethoxyphenol (CAS 622-62-8), both substituted monophenols. Under EU Regulation 1223/2009 Annex III, 4-ethoxyphenol is restricted for use as a substance in hair dye products (colours for skin application of the eyelashes and eyebrows are prohibited). Both compounds carry GHS hazard statements for skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). These are intermediate chemicals requiring careful handling and formulation control.

Skin benefits

  • Antioxidant properties
  • Historical use as stabilizer

Known concerns

  • EU Annex III restricted for hair dye use
  • H315 - skin irritation
  • H319 - serious eye irritation
  • H335 - respiratory irritation
  • Potential for skin sensitization

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.