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cloprednol

CAS 5251-34-3
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Cloprednol is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Cloprednol (6-chloro-11beta,17,21-trihydroxy-1,4-pregnadiene-3,20-dione) is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory activity. Like all topical steroids, it is regulated as a medicinal product in the EU and is explicitly prohibited from cosmetic formulations. The SCCS and EU cosmetics regulation distinguish clearly between cosmetic active ingredients and pharmacological agents. Cloprednol carries typical corticosteroid concerns including potential for skin barrier disruption, telangiectasia development, and systemic effects from prolonged topical use. The compound's presence in cosmetic databases is erroneous; it belongs exclusively in pharmaceutical/prescription drug classification.

Known concerns

  • Topical corticosteroid - prescription required
  • Not permitted in EU cosmetics
  • Skin atrophy risk
  • Systemic absorption potential
  • Medicinal product classification

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.