Synthetic signal peptide
HEXAPEPTIDE-66
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Hexapeptide-66 is a lab-made six-amino-acid chain promoted for anti-aging signaling effects. Like most cosmetic peptides it is well tolerated but evidence beyond supplier data is thin.
Function
Skin benefits
- Signal peptide marketed for skin firmness and elasticity
- Low irritation potential at typical use levels under 1%
- Water-soluble and compatible with most serum formats
Known concerns
- Limited independent peer-reviewed efficacy data
- Supplier-specific synthetic peptide with no CIR or SCCS review
- Stability and penetration claims rely on manufacturer studies
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related synthetic signal peptides
Check your shelf
Find HEXAPEPTIDE-66 in your products.
Scan any cosmetic product with LuxSense to see if it contains HEXAPEPTIDE-66 and get a full ingredient breakdown with safety scores.
This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.