Synthetic signal peptide
SH-HEXAPEPTIDE-9 SP ACETATE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A lab-made six-amino-acid peptide (acetate salt) used in anti-ageing creams to nudge skin towards making more collagen. Considered low-risk at typical use levels, though independent efficacy data is thin.
Skin benefits
- Synthetic hexapeptide marketed for collagen-supporting signalling in anti-ageing formulas
- Used at very low percentages, so systemic exposure is minimal
- Acetate salt form is water soluble and easy to formulate
- Generally well tolerated on intact skin in published patch testing of similar peptides
Known concerns
- Independent clinical evidence for SH-Hexapeptide-9 specifically is limited; most claims rely on supplier data
- Peptide stability in finished products varies; preservation systems may be needed
- Possible sensitisation in rare individuals as with any bioactive peptide
- Not assessed individually by SCCS; safety inferred from peptide class
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related synthetic signal peptides
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.