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NONOXYNOL-20

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

With an average of 20 ethylene oxide units, this higher-ethoxylated Nonoxynol has diminished endocrine activity but remains prohibited in EU cosmetic products under REACH restrictions.

Nonoxynol-20 is a nonionic surfactant of the polyethylene glycol mono(4-nonylphenyl) ether family. The higher ethoxylation degree substantially reduces its lipophilicity and its potential to degrade to free nonylphenol compared to lower-ethoxylated variants. Despite this improved profile, EU REACH Annex XVII entry 46a applies a class-level restriction to all nonylphenol ethoxylates in cosmetic formulations. Environmental concerns regarding aquatic toxicity and pseudo-persistence in sewage treatment effluents remain.

Known concerns

  • EU REACH Annex XVII restriction in cosmetic products
  • Residual endocrine disruption risk (nonylphenyl)
  • Aquatic toxicity
  • Environmental persistence in water systems

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.