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P-CHLOROPHENOL

CAS 106-48-9
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

P-Chlorophenol is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

p-Chlorophenol (4-chlorophenol) is a chlorinated aromatic compound historically used as an antiseptic and preservative. The phenolic hydroxyl and chlorine substitution create toxicological concerns including skin absorption, systemic toxicity at higher doses, and potential endocrine-disrupting activity. EU Regulation 1223/2009 does not explicitly list p-chlorophenol in Annex II or III, but the compound's toxicity profile and structural alerts raise concerns that have limited its use in modern cosmetics. The chlorine atom is relatively stable, reducing but not eliminating concerns about bioaccumulation. The SCCS has noted that chlorophenols may be present as impurities in other cosmetic ingredients and should be controlled to the lowest technically achievable levels.

Skin benefits

  • Antimicrobial preservative properties
  • Effective against broad spectrum of microorganisms

Known concerns

  • Skin absorption and systemic toxicity
  • Potential endocrine-disrupting activity
  • Environmental concerns regarding chlorinated phenols
  • Contaminant in other cosmetic ingredient streams

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.