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P-METHYLAMINOPHENOL

CAS 150-75-4
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An aminophenol hair dye intermediate used in oxidative coloration; restricted under EU Annex III (III/223) with concentration limits due to skin sensitization and toxicity concerns.

P-Methylaminophenol (also known as 4-methylaminophenol) functions as a primary intermediate in oxidative hair dye formulations, developing color through oxidative polymerization. The methylaminophenol structure creates toxicological concerns related to methemoglobin formation and potential genotoxicity. The EU Cosmetics Regulation 1223/2009 Annex III listing (reference III/223) imposes specific conditions on its use, limiting concentrations and requiring specific purity criteria to minimize contamination from related aniline derivatives. The SCCS has requested additional toxicological data for complete safety assessment of this class of hair dye intermediates.

Known concerns

  • EU Annex III restriction (III/223) with concentration limits
  • Methemoglobin formation potential
  • Skin sensitization and allergic contact dermatitis
  • Possible genotoxic impurities from aniline derivatives

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.