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4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride

CAS 159939-85-2
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An imidazole-substituted aromatic diamine with strong antimicrobial activity, this compound carries a severe hazard profile including acute toxicity, skin corrosion, sensitisation, reproductive toxicity, and environmental hazards — entirely unsuitable for cosmetic use.

This benzenediamine dihydrochloride derivative carries an exceptionally severe hazard profile: H302 (harmful if swallowed), H314 (causes severe skin burns and eye damage), H317 (may cause allergic skin reaction), H361f (suspected of damaging fertility — reproductive toxicity), and H411 (toxic to aquatic life with long-lasting effects). The Danger signal word and documented skin corrosion, respiratory sensitisation, and reproductive toxicity concerns place this compound firmly in the EU Annex II prohibited category for cosmetic skin products. Its imidazole antimicrobial pharmacophore is pharmacologically active and entirely inappropriate for cosmetic skin care use.

Known concerns

  • H314: Severe skin burns and eye damage
  • H302: Acute oral toxicity
  • H317: Skin sensitisation / allergic contact dermatitis
  • H361f: Suspected reproductive toxicity (CMR concern)
  • H411: Aquatic toxicity
  • Danger signal word — prohibited in cosmetic skin applications

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.