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6-NITRO-2,5-PYRIDINEDIAMINE

CAS 69825-83-8
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A nitro-substituted pyridine diamine hair dye intermediate with a very low PubChem safety score (5) and EU Annex II/1321 restriction, indicating significant safety concerns.

6-Nitro-2,5-pyridinediamine is a heterocyclic nitro-diamine used as a coupling agent in oxidative hair dye systems. It carries an extremely low PubChem safety score of 5, reflecting significant toxicological concerns. It is listed in EU Annex II/1321, prohibiting its use in cosmetic products in the EU. The combination of a nitro group with a heterocyclic diamine structure presents concerns for mutagenicity and skin sensitisation.

Known concerns

  • EU Annex II restricted (II/1321) - prohibited in EU cosmetic products
  • Very low safety score (PubChem: 5)
  • Potential mutagenicity from nitro-heterocyclic structure
  • Skin and respiratory sensitisation concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.