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4-NITRO-O-PHENYLENEDIAMINE

CAS 99-56-9
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-substituted phenylenediamine restricted under EU Annex III for oxidative hair dye use due to mutagenicity and sensitization concerns.

4-Nitro-o-phenylenediamine (2-nitro-1,4-diaminobenzene) is listed in EU Annex III of Regulation 1223/2009 (entry Annex III/240), restricting its use in oxidative hair dye products. The nitro group on this phenylenediamine creates significant mutagenicity concerns through nitroreduction pathways in vivo. It shows skin sensitization potential and has been associated with allergic contact dermatitis in hairdressers and consumers.

Skin benefits

  • Hair dye intermediate for oxidative coloration

Known concerns

  • EU Annex III restricted for hair dye use
  • H341 mutagenicity concern
  • Skin sensitizer
  • Nitroreduction metabolic activation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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4-NITRO-O-PHENYLENEDIAMINE HCL
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.