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Peptide active

NONAPEPTIDE-40

75

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Nonapeptide-40 is a synthetic skin-signaling peptide marketed for tone and pigmentation benefits. Cosmetic peptides at typical use levels are generally well tolerated, though independent evidence remains limited.

Function

SKIN CONDITIONING

Skin benefits

  • Synthetic nonapeptide marketed for skin-signaling and brightening effects
  • Studies suggest tyrosinase or melanin pathway modulation
  • Generally well tolerated at cosmetic concentrations

Known concerns

  • Limited independent clinical evidence
  • No SCCS-specific safety opinion published
  • Peptide stability and penetration variability between formulations
  • Possible irritation in sensitive skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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Scan any cosmetic product with LuxSense to see if it contains NONAPEPTIDE-40 and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.