Conditioning Agent
SH-POLYPEPTIDE-132
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human laminin subunit gamma-2 protein of 1193 amino acids produced in E. coli for skin conditioning.
A single-chain recombinant human Laminin Subunit Gamma-2 protein synthesized from a copy of the human LAMC2 gene, produced in E. coli. The protein contains up to 1193 amino acids with possible disulfide bonds and/or glycosylation. Laminin is a key extracellular matrix protein; human-derived recombinant versions have an established safety profile in cosmetic applications under EU EC 1223/2009.
Function
Skin benefits
- Skin conditioning through extracellular matrix protein support
Known concerns
- Large protein size increases immunogenicity risk
- Limited long-term human safety data for topical cosmetic use
- Potential for sensitization with repeated exposure
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.