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DECA (SH-POLYPEPTIDE-180)

83

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A ten-repeat synthetic polypeptide designed for use in advanced anti-aging and skin-conditioning cosmetic formulations.

Deca (sh-Polypeptide-180) is a synthetic peptide composed of ten repeats of sh-Polypeptide-180. Like other synthetic cosmetic peptides, it is not listed in any annexes of EU Cosmetics Regulation 1223/2009 and is considered safe for use in topical cosmetic preparations. The large molecular size limits penetration, supporting surface-level targeted benefits.

Skin benefits

  • Potential anti-aging and firming benefits
  • May support skin smoothness and texture

Known concerns

  • Rare individual hypersensitivity reactions possible

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.