Conditioning Agent
SILKWORM SH-OLIGOPEPTIDE-1
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant Epidermal Growth Factor produced in transgenic silkworms at 53 amino acids, supporting skin cell proliferation and renewal.
Silkworm sh-Oligopeptide-1 is a recombinant human EGF (up to 53 amino acids) produced in transgenic silkworm (Bombyx mori). EGF is a well-characterised growth factor stimulating cell proliferation. While the 53-amino-acid fragment used in cosmetics is smaller than full-length EGF, the inherent growth factor activity of this ingredient class warrants safety evaluation. Not listed in EU Annex II or III but growth factor peptides are subject to ongoing SCCS review.
Function
Skin benefits
- Skin conditioning
Known concerns
- EGF growth factor activity requires safety assessment
- Silkworm transgenic production
- Growth factor peptides under regulatory review
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.