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Peptide active

DIGALLOYL LYSYL SH-HEXAPEPTIDE-4

70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A synthetic SH-hexapeptide-4 modified with two gallate groups and a lysine linker, used as an anti-aging cosmetic active that combines peptide cell-signaling with polyphenolic antioxidant chemistry on the skin.

Skin benefits

  • Modified hexapeptide with antioxidant gallate moieties
  • Marketed for anti-aging and firming actions
  • Combines polyphenol and peptide mechanisms
  • Active at low use levels

Known concerns

  • Limited independent peer-reviewed clinical evidence
  • Possible sensitization in atopic individuals
  • Cost-driven proprietary actives often poorly disclosed
  • Stability of peptide depends on formulation pH

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related peptide actives

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ETHYL CARBAZIDO HYALURONATE ACETYL HEXAPEPTIDE-8
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SH-POLYPEPTIDE-132
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TETRAPEPTIDE-63 ACETATE
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TRIPEPTIDE-131 HCL
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NONAPEPTIDE-40
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SILKWORM SH-OLIGOPEPTIDE-1
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DECA (SH-POLYPEPTIDE-180)
Peptide active

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.