Conditioning Agent
PALMITOYL DIPEPTIDE-28 D-SERINE DIPEPTIDE-7 PALMITAMIDE
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A lipophilic peptide combining D-amino acids with palmitic acid modification for enhanced skin penetration, used as a skin conditioning agent with generally favorable safety but moderate sensitization potential.
This ingredient is a synthetic peptide consisting of Dipeptide-28, D-serine, and Dipeptide-7, with both N-terminus and lysine residues modified by palmitic acid (palmitoylation). The use of D-amino acids (rather than L-) reduces enzymatic degradation and can enhance stability. Palmitoylation increases lipophilicity, improving membrane penetration. Used as a skin conditioning agent, peptide-palmitate combinations are well-established in cosmetics (e.g., Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7). EU CosIng lists no specific restrictions. The D-amino acid composition reduces but does not eliminate sensitization potential.
Function
Skin benefits
- Skin conditioning agent
- Enhanced skin penetration from lipophilic modification
- D-amino acids provide stability against enzymatic degradation
- May support collagen synthesis similar to other palmitoyl peptides
Known concerns
- Palmitic acid modification may increase skin penetration requiring purity controls
- Sensitization potential exists though D-amino acids reduce this
- Contains palmitoyl moiety which is a skin-derived lipid - generally well-tolerated
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.