Skin Conditioning
TYROSYL HISTIDINE HCL
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A simple dipeptide of tyrosine and histidine, sold as hydrochloride salt. Natural amino acid origin, generally well tolerated.
Tyrosyl histidine HCl (CAS 94111-42-9) is the hydrochloride salt of the dipeptide formed from tyrosine and histidine, two naturally occurring proteinogenic amino acids. It acts as a skin-conditioning agent and mild antioxidant. The parent amino acids have extensive food-grade and pharmaceutical safety data, and small peptides of this type are generally non-irritating and non-sensitizing at cosmetic use levels. No dedicated SCCS or CIR review identified for this specific dipeptide, but the mechanism and precedent chemistry are well understood. No GHS hazards apply.
Function
Skin benefits
- Simple dipeptide of naturally occurring amino acids
- Mild antioxidant activity
- Used at trace levels with negligible irritation potential
Known concerns
- Limited cosmetic-specific efficacy data
- Histidine moiety could theoretically chelate metals in formulation
- No dedicated regulatory review
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.