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SH-POLYPEPTIDE-153

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic human peptide modeled after Transcription Factor E2F1 — a biologically active sequence intended to support skin cell renewal and repair through gene regulation pathways.

sh-Polypeptide-153 is a recombinant human peptide produced in E. coli, based on a synthesized copy of the human E2F1 gene. E2F1 (E2F Transcription Factor 1) is a nuclear protein that regulates cell cycle progression and apoptosis. In skincare, synthetic E2F-derived peptides are used for their potential to support skin renewal and repair at the gene expression level. At 437 amino acids, it is a relatively large peptide for topical application. The functional relevance of transcription factors in topical cosmetics remains an emerging area.

Function

HUMECTANT

Skin benefits

  • supports skin cell renewal pathways
  • humectant hydration
  • potential anti-aging benefits

Known concerns

  • transcription factor activity raises theoretical concerns about gene expression modulation
  • requires rigorous purification from bacterial endotoxins

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.