Antioxidant
SH-POLYPEPTIDE-89
Safety score · 0–100
Good
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A recombinant human hyaluronan synthase 1 protein (578 amino acids) produced in E. coli, supporting skin hydration as a humectant.
A single-chain synthetic human Hyaluronan Synthase 1 protein produced via E. coli fermentation. Contains up to 578 amino acids with possible disulfide bonds and/or glycosylation. HAS1 produces hyaluronic acid, a key skin hydration component. Human-derived recombinant enzymes have favorable safety profiles in cosmetic applications under EU regulation EC 1223/2009.
Function
Skin benefits
- Antioxidant protection for skin
- Humectant hydration properties
- Skin conditioning through hyaluronic acid pathway support
Known concerns
- Large protein size increases immunogenicity risk
- Limited long-term human safety data for topical cosmetic use
- Potential for sensitization with repeated exposure
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related antioxidants
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.