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buphenine

CAS 447-41-6
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Buphenine is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Buphenine (also known as nylidrin) is a beta-adrenergic agonist that causes peripheral vasodilation and smooth muscle relaxation. It is used as a prescription drug for vascular disorders in some countries. It is not listed in EU Cosmetics Regulation (1223/2009) Annexes I–VI as an approved cosmetic ingredient. Beta-agonists are regulated as medicinal products rather than cosmetics ingredients.

Known concerns

  • Not an approved cosmetic ingredient in EU
  • Regulated as a medicinal substance
  • Cardiovascular effects (palpitations, hypotension)
  • Limited cosmetic-relevant safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.