Other
Chlormezanone (INN)
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Chlormezanone (INN) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
Chlormezanone is a thiadiazine derivative that acts as a centrally acting muscle relaxant and anxiolytic. It was marketed in several countries but was withdrawn globally following reports of severe adverse drug reactions including hepatotoxicity, Stevens-Johnson Syndrome (SJS), and Toxic Epidermal Necrolysis (TEN) – life-threatening cutaneous reactions. The INN (International Nonproprietary Name) designation confirms its pharmaceutical rather than cosmetic development. Its withdrawal from all markets and documented severe toxicity makes it wholly incompatible with cosmetic use.
Known concerns
- Globally withdrawn from all markets
- Hepatotoxicity – serious liver toxicity
- SJS/TEN – life-threatening skin reactions
- No cosmetic use – prescription drug only
- Not authorized under EU cosmetic regulations
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.