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CIS-RETINOIC ACID

CAS 4759-48-2 Updated
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A biologically active retinoid (CAS 4759-48-2, isotretinoin/13-cis-retinoic acid) heavily restricted in EU cosmetics. Prohibited in leave-on products and prescription-only when used systemically due to teratogenicity.

Function

ANTI-SEBUM

Skin benefits

  • Not permitted for cosmetic leave-on use in EU

Known concerns

  • EU Annex II prohibition for leave-on cosmetics
  • Severe teratogenicity (oral)
  • Strong skin irritation
  • Prescription-only drug

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.