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DOCOSYLOXYMETHOXYBENZYL AZAFULLERENEDIONE

CAS 943912-75-2
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A fullerene-derivative nanomaterial with undefined safety profile for topical application and no EU cosmetic authorisation — primarily a research material with unknown dermal toxicity.

Docosyloxymethoxybenzyl azafullerenedione is a functionalised fullerene (C60 or C70 core) with a long-chain alkoxybenzyl substituent and an azafullerene (nitrogen-doped) framework. Fullerene derivatives are under active research for antioxidant (radical scavenging) and photoprotective properties, but safety data for chronic topical cosmetic use remain insufficient. The nanomaterial nature raises additional concerns about dermal penetration, biodistribution, and environmental implications under EU Regulation 1223/2009 and the EU definition of nanomaterials. No SCCS opinion exists for this specific derivative, and it does not appear in CosIng. The complete absence of regulatory assessment and the novel chemical entity status drive the low score.

Skin benefits

  • Potentially strong antioxidant (fullerene radical scavenging) — research stage
  • Potential photoprotective properties — not clinically established

Known concerns

  • No EU CosIng authorisation — not listed as permitted cosmetic ingredient
  • Nanomaterial — potential for dermal penetration and systemic distribution
  • No SCCS safety assessment available
  • No REACH registration relevant to cosmetic use
  • Unknown chronic topical toxicity and sensitisation profile
  • Environmental concerns for nanomaterial waste

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.