Other
doxylamine
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Doxylamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.
Doxylamine succinate is a first-generation H1-antihistamine used in oral over-the-counter sleep aids (e.g., Unisom). Its pharmacological activity (CNS depression) makes it unsuitable for cosmetic application, and it is not listed in EU Regulation (EC) No 1223/2009 Annexes I–VI with authorized use. Topical antihistamines can cause skin sensitization. The ingredient may occasionally appear in raw material impurity profiles but is not intentionally added as a cosmetic functional ingredient.
Known concerns
- Pharmacological CNS depressant not appropriate for cosmetics
- H1-antihistamines can cause skin sensitization on topical application
- No EU cosmetic authorization
- May cause drowsiness in systemic exposure
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.