Skip to content

Other

doxylamine

CAS 469-21-6
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Doxylamine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Doxylamine succinate is a first-generation H1-antihistamine used in oral over-the-counter sleep aids (e.g., Unisom). Its pharmacological activity (CNS depression) makes it unsuitable for cosmetic application, and it is not listed in EU Regulation (EC) No 1223/2009 Annexes I–VI with authorized use. Topical antihistamines can cause skin sensitization. The ingredient may occasionally appear in raw material impurity profiles but is not intentionally added as a cosmetic functional ingredient.

Known concerns

  • Pharmacological CNS depressant not appropriate for cosmetics
  • H1-antihistamines can cause skin sensitization on topical application
  • No EU cosmetic authorization
  • May cause drowsiness in systemic exposure

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related others

25
(4-Phenylbutyl)phosphinic acid
Other
 25
2,2'-METHYLENEBIS 4-AMINOPHENOL
Other
 25
2-AMINO-4-NITROPHENOL SULFATE
Other
 25
4-NITRO-O-PHENYLENEDIAMINE
Other
 25
4-NITRO-O-PHENYLENEDIAMINE HCL
Other
 25
4-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride
Other
 25
6-NITRO-2,5-PYRIDINEDIAMINE
Other
 25
ALUMINUM FLUORIDE
Other

Check your shelf

Find doxylamine in your products.

Scan any cosmetic product with LuxSense to see if it contains doxylamine and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.