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METHYL AMINOLEVULINATE HCL

CAS 79416-27-6
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Methyl Aminolevulinate Hcl is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Methyl Aminolevulinate HCl (methyl aminolevulinate hydrochloride) is a photosensitizing prodrug that generates protoporphyrin IX upon light exposure, used in prescription photodynamic therapy (PDT) for dermatological conditions. In the EU, aminolevulinic acid and its derivatives are restricted under Cosmetics Regulation Annex III (Entry 306), limiting maximum concentration to 8% for professional use only. The compound carries phototoxicity warnings and is classified as a potential carcinogen (IARC Group 2A); home use is prohibited.

Skin benefits

  • Used in prescription photodynamic therapy for actinic keratosis
  • Treats certain skin cancers and pre-cancerous lesions when combined with controlled light exposure
  • Professional-use only skin renewal treatment

Known concerns

  • Photosensitizing agent - increases UV sensitivity
  • Restricted to professional/prescription use in EU (Cosmetics Regulation Annex III, Entry 306)
  • Potential carcinogen (IARC Group 2A)
  • Maximum concentration limited to 8% in professional formulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.