Other
methylprednisolone
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Methylprednisolone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Methylprednisolone is a synthetic glucocorticoid corticosteroid used systemically in pharmaceuticals for its anti-inflammatory and immunosuppressive effects. Topical corticosteroids are regulated under EU Cosmetics Regulation and are not permitted in cosmetic products beyond very low concentrations in specially regulated categories. As a systemic pharmaceutical agent, its inclusion in skin care formulations raises significant safety concerns.
Skin benefits
- Anti-inflammatory (pharmaceutical use only)
Known concerns
- Synthetic corticosteroid with systemic activity
- Skin atrophy with prolonged topical use
- Not authorised for general cosmetic formulations under EU regulation
- Potential HPA axis suppression from percutaneous absorption
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.