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methylprednisolone

CAS 83-43-2
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Methylprednisolone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Methylprednisolone is a synthetic glucocorticoid corticosteroid used systemically in pharmaceuticals for its anti-inflammatory and immunosuppressive effects. Topical corticosteroids are regulated under EU Cosmetics Regulation and are not permitted in cosmetic products beyond very low concentrations in specially regulated categories. As a systemic pharmaceutical agent, its inclusion in skin care formulations raises significant safety concerns.

Skin benefits

  • Anti-inflammatory (pharmaceutical use only)

Known concerns

  • Synthetic corticosteroid with systemic activity
  • Skin atrophy with prolonged topical use
  • Not authorised for general cosmetic formulations under EU regulation
  • Potential HPA axis suppression from percutaneous absorption

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.