Other
N-METHOXYETHYL-P-PHENYLENEDIAMINE HCL
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A hair dye intermediate regulated under EU Annex II/1226, reflecting its classification as a substance requiring particular scrutiny in oxidative hair dye formulations due to sensitisation and potential toxicity.
N-Methoxyethyl-p-phenylenediamine HCl is an aromatic amine hair dye precursor in the p-phenylenediamine (PPD) class. Hair dye intermediates in this class are subject to stringent EU regulation due to their well-documented capacity for causing severe allergic contact dermatitis. The restriction reference II/1226 in CosIng indicates this compound falls under Annex II of the EU Cosmetics Regulation, which lists substances that are restricted in certain cosmetic applications. Oxidation hair dyes incorporating PPD derivatives can form reactive quinone species capable of binding to skin proteins and triggering immune-mediated sensitisation.
Known concerns
- EU Annex II restricted — not authorised for general cosmetic use without specific restriction
- Known skin sensitiser in the PPD class of hair dye intermediates
- Potential for severe allergic contact dermatitis
- Forms reactive oxidation products in ambient and developer conditions
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.