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Conditioning Agent

R-SACCHAROMYCES/METHIONYL S-OCEAN POUT TYPE-3 ICE STRUCTURING PROTEIN HPLC 12

82

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A recombinant ice-structuring protein from Antarctic ocean pout produced in yeast, analogous to fish antifreeze proteins and used for skin conditioning in cosmetics.

This recombinant protein is identical in sequence to the Type-3 Ice Structuring Protein found in the ocean pout (Zoarces americanus), expressed in Saccharomyces cerevisiae. Ice-structuring proteins (also called antifreeze proteins) are naturally occurring in cold-water fish and have been studied for cryoprotective and membrane-stabilising properties. Saccharomyces expression avoids the endotoxin issues associated with E. coli. The ingredient is not listed in EU restriction annexes and has a favourable safety profile given the natural origin of the source protein and the clean yeast expression platform.

Function

SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Skin conditioning (miscellaneous) through membrane stabilisation
  • May support skin resilience against environmental stress

Known concerns

  • Fish-derived protein may pose allergenicity risk for seafood-allergic consumers
  • Limited market history in cosmetic formulations
  • Cold-climate fish protein may contain unfamiliar epitopes

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.