Other
TOLUENE-2,5-DIAMINE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A toluene-derived diamine hair dye intermediate restricted in the EU under Annex III, with known skin sensitization and toxicity concerns.
Toluene-2,5-diamine (also called p-toluene-2,5-diamine or 2,5-diaminotoluene) is one of the classic primary intermediates in oxidative hair dyeing. EU CosIng lists it under Annex III restriction reference III/9a, meaning it is permitted only under specified restrictions. The compound is a known skin sensitizer, and the SCCS has assessed it multiple times, setting safe concentration limits due to concerns about oxidation to quinone-diimine derivatives and potential for binding to skin proteins. The 2,5-substitution pattern places both amino groups on the same aromatic ring, creating a potent sensitizing structure.
Skin benefits
- Primary hair dye intermediate enabling grey coverage and tone development
- Couples with various developers for broad shade range
Known concerns
- EU Annex III restricted (III/9a) with specific concentration limits
- Known skin sensitizer with H317 classification
- Oxidation to quinone-diimine raises toxicological concern
- SCCS has set specific limits requiring in-use testing confirmation
- Cross-reactivity with other aromatic amine hair dye intermediates
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.