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TOLUENE-2,5-DIAMINE

CAS 95-70-5
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A toluene-derived diamine hair dye intermediate restricted in the EU under Annex III, with known skin sensitization and toxicity concerns.

Toluene-2,5-diamine (also called p-toluene-2,5-diamine or 2,5-diaminotoluene) is one of the classic primary intermediates in oxidative hair dyeing. EU CosIng lists it under Annex III restriction reference III/9a, meaning it is permitted only under specified restrictions. The compound is a known skin sensitizer, and the SCCS has assessed it multiple times, setting safe concentration limits due to concerns about oxidation to quinone-diimine derivatives and potential for binding to skin proteins. The 2,5-substitution pattern places both amino groups on the same aromatic ring, creating a potent sensitizing structure.

Skin benefits

  • Primary hair dye intermediate enabling grey coverage and tone development
  • Couples with various developers for broad shade range

Known concerns

  • EU Annex III restricted (III/9a) with specific concentration limits
  • Known skin sensitizer with H317 classification
  • Oxidation to quinone-diimine raises toxicological concern
  • SCCS has set specific limits requiring in-use testing confirmation
  • Cross-reactivity with other aromatic amine hair dye intermediates

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.