Antioxidant
SR-(METHIONYL S-RAINBOW TROUT OLIGOPEPTIDE-1 SH-POLYPEPTIDE-149 HEXAPEPTIDE-40)
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A 388-residue E. coli fusion peptide combining rainbow trout sequence with a large human-mimicking polypeptide domain, serving as an antioxidant and multi-functional skin/hair ingredient.
This is one of the largest fusion peptides in the batch at 388 amino acids, combining rainbow trout s-Oligopeptide-1, sh-Polypeptide-149, and Hexapeptide-40. The large molecular size significantly limits skin penetration, consistent with SCCS guidance that peptides above ~500 Da have minimal dermal absorption. No EU restrictions apply; the ingredient is subject to general product safety provisions under Regulation (EC) No 1223/2009 Article 3. The recombinant protein is produced in E. coli and purified via standard chromatography steps.
Function
Skin benefits
- Antioxidant activity
- Skin protecting and humectant functions
- Hair conditioning
Known concerns
- Large size limits bioavailability; may not reach viable skin layers
- Endotoxin risk from E. coli requires control
- Fish allergenicity risk
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.